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first_imgAcute leukaemia has a high relapse rateScientists are working on a way to stop one of the most aggressive forms of acute leukaemia, MLL, returning after a patient has received treatment.Recurrence of the blood cancer caused by rogue leukaemic stem cells is a major problem for doctors.But a team at King’s College London, working on mice, have raised hopes of a solution.They describe in the journal Cell Stem Cell how they eliminated the stem cells by suppressing two key proteins.It is hoped the work, funded by Cancer Research UK and Leukaemia Lymphoma Research, will lead to new treatments which will enable complete remission for patients with a form of acute leukaemia.Cancer stem cells appear to be more resistant than other leukaemia cells to standard treatments, such as radiotherapy and chemotherapy.So even after treatment appears to have been initially successful, they can remain to trigger a new round of disease, which often reappears in a more aggressive form.More than 50% of acute leukaemia patients will relapse and survival is poor, with fewer than half living for five years.The King’s team looked at leukaemic stem cells found in a type of acute leukaemia involving mutations in a gene called MLL.This particularly aggressive form of the disease accounts for about 70% of infant leukaemias, and 10% of adult acute leukaemias.Only half of children diagnosed with the disease survive for two years after receiving standard treatment.Double assaultA protein called Bmi1 was already known to play a key role in the survival and proliferation of various cancer stem cells.But the King’s team showed that targeting Bmi1 alone was not enough to eradicate the rogue stem cells, as had previously been thought. To do that, the scientists found that Bmi1 had to be targeted in harness with a second protein, Hoxa9.This double assault abolished the ability of MLL mutation to induce leukaemia.Researcher Professor Eric So said: “These findings take us a step forward in our understanding of how this devastating disease can return in patients after they have received the standard treatment.“Now we know that leukaemic stem cells in certain types of leukaemia, such as MLL, can survive and proliferate independently of the Bmi1 protein, we need to consider more carefully the future of stem cell therapy to treat the disease.“It’s not as easy as people originally thought it might be.”Professor So said the next step would be to pin down exactly how the two proteins help cancer cells to grow.Professor Peter Johnson, Cancer Research UK’s chief clinician, said: “Cancer stem cells appear to be more resistant to radiotherapy and chemotherapy than the other leukaemia cells, so understanding how they originate – and how we can kill them – will be a major step in being able to help even more people survive leukaemia in future.”Dr David Grant, scientific director of Leukaemia & Lymphoma Research, said: “It is now widely agreed that leukaemia stem cells are the true target for new or existing drugs if patients are to be cured.“This research is important in uncovering how leukaemia stem cells are controlled at the genetic level which in turn will guide new treatments to tackle this difficult problem.”BBC News Share HealthLifestyle Hopes raised of blocking return of leukaemia by: – June 4, 2011 Share Sharing is caring!center_img Share 15 Views   no discussions Tweetlast_img read more

first_imgSenator Dan Coats (R-Indiana)OSGOOD – U.S. Senator Dan Coats (R-Ind.) announces that a member of his staff will visit Osgood from 1-3 p.m. Friday.The goal is to meet with local residents and assist anyone experiencing issues with a federal agency.Citizens are invited to attend the free event at the Osgood Town Hall on W. Ripley Street.last_img

first_imgPerhaps no one put it better than USC baseball’s interim coach, Frank Cruz: “The better team won today,” Cruz said, following the Trojans’ 5-2 loss to UC Santa Barbara.Daily TrojanIt was the Trojans’ first chance to avenge a midweek loss, as the Gauchos beat the Trojans 3-2 in Santa Barbara previously this month.The Gauchos got on top right away. With two on and one down in the first, cleanup hitter Mark Haddow ripped a two-RBI double into the gap in left center.USC got a run back in the second. Sophomore right fielder Alex Glenn was hit by a pitch with one out and went to third on a single to right by sophomore third baseman Adam Landecker.With two down, junior catcher Kevin Roundtree delivered the clutch knock through the right side to plate Glenn for his first RBI of the year.Junior starter Ben Mount got tagged with another pair in the third, again by Haddow.It was another shot to left center, but this one went over the fence for a two-run homer to put the Gauchos up 4-1, and Mount was lifted from the game after going just two and two-thirds innings, allowing four earned runs, and raising his season ERA from 1.10 to 2.84.Junior first baseman Ricky Oropesa led off with a double in the fourth.He advanced to third on a groundout and scored on a single by junior designated hitter Brandon Garcia, but that was it for the Trojans in that inning.All told, USC left seven runners on base in the first four innings, including runners in scoring position in the first, third and fourth.The Trojans have left nearly eight men per game on base in their 21 games this season.“We gotta start putting the bat on the ball with runners on,” Cruz said. “Maybe be a little more aggressive. But we gotta get that done.”UCSB also made a pitching change after the third, and new pitcher Nick Capito delivered three scoreless innings.He was matched by freshman reliever Kyle Richter, who retired the Gauchos in order in the fourth and fifth and got the first two in the sixth before he was pulled after three of his own shutout innings.“Richter was a bright spot,” Cruz said. “One of the few.”Back-to-back singles by freshman shortstop James Roberts and Oropesa put a pair on in the Trojans’ half of the seventh. A steal put runners at second and third with two down for Garcia.After falling behind 0-2, he worked it to 2-2 before UCSB made a pitching change. Cruz countered with junior pinch hitter Mike Greco.So brand new Gaucho pitcher Connor Whalen prepared to throw his first pitch of the game to Greco, the brand-new Trojan hitter, with a 2-2 count.After taking a ball to work the count full, Greco took a fastball on the outside corner for strike three.USC put two on again in both the eighth and ninth, but couldn’t get the runners home either time to finish with 13 left on for the game.“We’re trying to do a little too much right now,” Oropesa said. “We just gotta drive it hard. As a hitter you just gotta get your pitch and hit it hard. That’s all you can do.”The Trojans will begin a weekend series at home Friday when UCLA comes to Dedeaux Field for three games. USC most recently beat the Bruins 2-0 on March 13 in a nonconference game at Dodger Stadium as a part of the Dodgertown Classic.last_img read more