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first_imgSep 29, 2006 (CIDRAP News) – Indonesia reported its 69th H5N1 avian influenza case today, in the 21-year-old sister of an 11-year-old boy who died of the same disease on Sep 18.The woman from the Tulungagung district of East Java tested positive for H5N1 today, 4 days after she was hospitalized, according to a Bloomberg News report. The World Health Organization (WHO) confirmed her 11-year-old brother’s case on Sep 25.The WHO had reported that poultry in the boy’s household began dying in the month prior to symptom onset, and poultry deaths continued in his neighborhood.An Indonesian official said it was unlikely that the woman caught the virus from her brother. “They’re genetically susceptible to the virus, which they were both exposed to from infected poultry,” health ministry official I Nyoman Kandun told Bloomberg. He said there was no evidence that the virus was passed from one sibling to the other.Meanwhile, a 20-year-old man cited by the WHO as Indonesia’s 68th case died yesterday, the WHO said. He is the 52nd Indonesian to die of the illness.The man was one of three siblings in Bandung, West Java, who had flu symptoms at the same time, which sparked concern about possible person-to-person transmission. His 23-year-old brother died Sep 24, and the WHO said H5N1 infection was suspected in his case, but it couldn’t be confirmed because no samples were taken. Both men had fed dead chickens to their dogs, and there was evidence of H5 infection in household birds.The 15-year-old sister of the two men was hospitalized Sep 25 with a fever and cough and was hospitalized in stable condition, the WHO said on Sep 27. Initial tests pointed to normal seasonal flu rather than avian flu, the agency said. Indonesian health officials yesterday ruled out person-to-person transmission of H5N1 among the three siblings, according to an Agence France-Presse report.On Java island, avian flu disease may have infected a quarter of backyard poultry in some of the country’s most densely populated areas, according an Indonesian veterinary official quoted in a Bloomberg News report today.Musny Suatmodjo, Indonesia’s director of animal health, said random tests on Java, where the virus is most prevalent, detected the H5N1 strain in as much as 27% of fowl and caged birds. He gave no details about how many birds were tested or when the survey was done.”The backyard sector is the weakest link,” he told Bloomberg News. “The survey of hotspots in the backyard sector showed almost every flock has been previously infected,” though not all birds showed symptoms.”In other avian flu news, China has shared some long-awaited samples of the H5N1 virus from birds, and many scientists are hailing the move as a breakthrough in cooperation, a WHO official said yesterday.The Chinese Ministry of Agriculture sent the samples, taken from some of the thousands of wild birds that died at Qinghai Lake in April 2005, to the US Centers for Disease Control and Prevention (CDC) in Atlanta, according to a Reuters report yesterday.WHO scientist Michael Perdue told a news briefing that the samples are the first bird specimens from China in two and a half years and will help researchers understand the origin of an H5N1 strain that later circulated in Turkey and Africa. The strain is genetically different from the one that moved through other parts of Asia, including Indonesia, Thailand, and Vietnam.The lake where the samples were collected is an important layover point for migratory birds in the remote northern Qinghai province, the Reuters report said.In March, China had promised to send up to 20 poultry samples to a WHO-affiliated laboratory outside the country. Samples were delayed because of reported communication lapses and disagreements between China and the CDC about the protocol and logistics for mailing the samples. However, the CDC said the problems were resolved in early September.Perdue said CDC officials expected to receive the samples yesterday, and he hoped the shipment would include additional animal samples requested from China, Reuters reported.”We have to wait to see exactly what they shipped,” he said.China had not shared avian flu virus samples from poultry since late 2004, according to recent news reports. Poultry H5N1 viruses, especially those from China, are needed to develop vaccines and drugs.See also:Sep 28 WHO statementhttp://www.who.int/csr/don/2006_09_28/en/index.htmlSep 27 WHO statementhttp://www.who.int/csr/don/2006_09_27a/en/index.htmlSep 25 WHO statementhttp://www.who.int/csr/don/2006_09_25/en/index.htmlSep 11 CIDRAP News article “Way cleared for China to share H5N1 samples”last_img read more

first_img Published on September 12, 2019 at 1:29 am Facebook Twitter Google+ Chase Brice’s 4th-and-6 completion and Clemson’s game-winning touchdown drive in the final minute of last season’s meeting propelled the Tigers past Syracuse, 27-23. The Orange upset Clemson in the Carrier Dome in 2017, and nearly pulled off a second consecutive upset last year at Clemson.This season, Clemson is No. 1, and the Orange were just pummeled, 63-20, against Maryland.Here’s what our beat writers predict will happen when No. 1 Clemson visits Syracuse on Saturday night:Eric Black (1-1)Orange Paper TigersClemson 38, Syracuse 24After last week’s embarrassing loss to Maryland, SU head coach Dino Babers said he knew his defense wasn’t as bad as it appeared versus the Terps, but also wasn’t as good as it looked in the season opener. Rather, the Syracuse defense is somewhere in between and still, Babers hopes, one of the strengths of the team. It’ll need to play up to its potential against the Tigers, and even then, that may not be enough for the Orange to pull off the upset. That’s not to say it won’t be close, though. There’s something about playing Clemson that prompts SU to play its best football, as evidenced by the last two      matchups. I think we’ll see more of the same through the first two or three quarters but between the talent disparity and Syracuse not playing great football right now, the Tigers should pull away late.AdvertisementThis is placeholder textAndrew Graham (1-1)RegressionClemson 38, Syracuse 17For two-straight seasons, Syracuse punched way above its weight class, beating and then almost upsetting again, the Clemson Tigers when the two met on the football field. Of course, we all know the last time Clemson played in the Carrier Dome, the Orange pulled a stunning upset. We saw them last season almost do the same in Death Valley.But this year, it seems unlikely, almost impossible, that SU gives the Tigers a third close game. Will it be a 54-0 drubbing like 2016, when Eric Dungey got knocked out? Doubt it. (An aside: The last three matchups, one team has lost its starting quarterback for the remainder of the game every time.) But there’s a reality to be addressed here. While Syracuse has grown in leaps and bounds, we saw last weekend how there’s still a ways to go. And Clemson looks as dominant as ever. While the Orange won’t get blown out, they won’t make it particularly close. It’s a regression to the mean.Josh Schafer (1-1)OutmatchedClemson 41 Syracuse 20Last year Syracuse stayed with Clemson for three quarters, even leading by 10 points in the final frame, but couldn’t hang with the Tigers in the fourth quarter. This season, as Clemson rolls out a two-deep full of four- and five-star recruits, could be remarkably similar. Clemson doesn’t have the defensive line it’s had in the past, but what it returns on offense in two potential Heisman candidates at quarterback and running back is just as lethal. Running back Travis Etienne exposed a new group of Syracuse linebackers last season to the tune of 203 rushing yards, and with 258 through two games, Saturday could be a repeat of last year. After 63 points allowed against Maryland, the likes of Trevor Lawrence and Etienne are a tough transition for the Orange. Syracuse’s offense showed glimpses of promise last week. With the largest crowd the Orange have had in years, Syracuse can stay with Clemson early, but as the game wears on, the Tigers just have too much top level talent for SU to hang on. Commentslast_img read more

first_img Ji So-Yun scores Chelsea Ladies FA Cup winning goal Chelsea Ladies claimed the first major trophy in their history by defeating Notts County Ladies 1-0 in the SSE Women’s FA Cup final at Wembley.South Korean Ji So-Yun’s goal eight minutes before half-time ensured Emma Hayes’ side were victorious in front of a record attendance of 30,701 in north London.It was the first time the showpiece event had been staged at the national stadium and Ji, whose winner in the semi-final against Manchester City took Chelsea to Wembley, made the key contribution after some good work from the excellent Eniola Aluko.It provided a historic piece of silverware for the Blues’ trophy cabinet and kept alive a possible Wembley double for Chelsea this weekend, with their male counterparts facing Arsenal in the Community Shield on Sunday.Neither side took control of the contest in the opening stages but the lively Aluko helped Chelsea find another gear on the half-hour mark.The 28-year-old, whose brother Sone Aluko was a beaten finalist in the men’s version with Hull in 2014, latched on to a through ball from the right and nipped past goalkeeper Carly Telford only to clip her effort into the side netting as the angle rapidly narrowed.Aluko was emerging as Chelsea’s biggest threat and she then forced Telford to fist away her swerving shot after robbing England team-mate Laura Bassett and skipping in from the left.The Lady Pies had no answer to Aluko’s pace and Chelsea should have been 1-0 up when her centre was somehow hooked back across the face of goal and wide by Gemma Davison inside the six-yard box.However, moments later Aluko was instrumental in giving the Blues the lead.Once more she drove in from the left and shuffled a pass inside from the incoming Ji. Although the South Korean’s touch appeared to have prevented a clear shot at Telford’s goal, a fortunate ricochet into her path allowed Ji to prod in a 37th-minute opener.Notts County’s best spell came during back-to-back corners early in the second half, with Desiree Scott almost equalising on the hour.She took a half-cleared corner down brilliantly on her instep before firing a sweetly-struck half volley which Gilly Flaherty’s head deflected narrowly past a post.From the resulting corner, Davison was needed on the back post to smash away a Leanne Crichton header that would have crept in the bottom corner.Chelsea then had a glorious chance to wrap it up with 17 minutes remaining, yet an unmarked Flaherty stabbed over from close range after Aluko’s clever flick found her six yards out.But Ji’s goal proved enough as the Blues held on for a richly-deserved triumph in front of a national television audience. 1last_img read more

first_imgMay 15 2018The seemingly unrelated conditions of hypertension, epilepsy and overactive bladder may be linked by electrical activity in a protein long studied by a biomedical engineer at Washington University in St. Louis.After new technology recently revealed the structure of the protein, the lab of Jianmin Cui, professor of biomedical engineering in the School of Engineering & Applied Science, will collaborate with two others to take an unprecedented look into its molecular mechanisms potentially leading to the development of new drugs for these and other conditions.Cui has received a four-year, $2.9 million grant from the National Institutes of Health to study the BK (big potassium) channel proteins in collaboration with labs from the University of Missouri-Columbia and the University of Massachusetts. The labs will each play a role in identifying new compounds that could go into the drug development pipeline.Cells have ion channels across the cell membrane, which are pathways that conduct electrical currents into or out of the cell and open in response to physical signals, such as voltage, or chemical signals, such as calcium ions. But these channels typically allow only one type of ion to pass through, for example, the BK channel only allows potassium to pass through.Recently, another lab used a new, Nobel-Prize-winning method called cryo-electron microscopy that allowed them to see the structure of the BK channel, which has given Cui’s lab a fresh look at the channel’s mechanisms. While researchers already knew the channel has three different domains -; the voltage-sensing domain, the cytosolic domain and the pore domain-; they do not know how sensors in other domains open the gate in the pore domain. Cui’s lab seeks to find that pathway.”In BK channel, the question is how would calcium binding in the cytosolic domain open the pore in the transmembrane pore domain,” Cui said. “We have the structural information, but the structure itself cannot answer the question of how the two domains will interact to propagate and transfer the movements in calcium binding that causes the cytosolic domain to open.”Related StoriesMother calls for protein shake regulation after daughter diesQuorn protein stimulates muscle building to a greater extent than milk proteinScientists discover hundreds of protein-pairs through coevolution studyTo answer the question, a lab at the University of Missouri-Columbia will identify chemical compounds that would bind and modify the channel protein to probe the parts of the channel protein that move upon calcium binding. They will pick out those compounds from a library of about a quarter of a million chemicals with known structures stored in computers. They will compare the structures of these chemicals one by one to potential sites in the channel protein using computers in an operation called docking, which may identify a handful of chemical compounds that might bind to the channel protein. Then they will apply the real compound of these hits from the in silico (in computer) screening to treat BK channels in cells and test if they modify channel function.At the University of Massachusetts, a team will simulate the motion of part of the protein to see if those motions are important in propagating the calcium-binding-induced movements to the pore.Finally, Cui’s lab will study the function of the channels by recording ionic currents flowing through these channels. These recordings, in combination with mutating the channel protein and some molecular modeling, will allow the lab to determine if the changes they see in the experiments and in simulation are factors for propagation.”We want to know where the structure changes, how does it change and what makes it change,” Cui said. “These understandings, along with the identification of compounds and their binding sites, could lead to the development of drugs for treating BK channel-related diseases.” Source:https://source.wustl.edu/2018/05/an-unprecedented-look-into-the-protein-behind-hypertension-epilepsy-and-other-conditions/last_img read more