Tag: 爱上海FG

first_img Ji So-Yun scores Chelsea Ladies FA Cup winning goal Chelsea Ladies claimed the first major trophy in their history by defeating Notts County Ladies 1-0 in the SSE Women’s FA Cup final at Wembley.South Korean Ji So-Yun’s goal eight minutes before half-time ensured Emma Hayes’ side were victorious in front of a record attendance of 30,701 in north London.It was the first time the showpiece event had been staged at the national stadium and Ji, whose winner in the semi-final against Manchester City took Chelsea to Wembley, made the key contribution after some good work from the excellent Eniola Aluko.It provided a historic piece of silverware for the Blues’ trophy cabinet and kept alive a possible Wembley double for Chelsea this weekend, with their male counterparts facing Arsenal in the Community Shield on Sunday.Neither side took control of the contest in the opening stages but the lively Aluko helped Chelsea find another gear on the half-hour mark.The 28-year-old, whose brother Sone Aluko was a beaten finalist in the men’s version with Hull in 2014, latched on to a through ball from the right and nipped past goalkeeper Carly Telford only to clip her effort into the side netting as the angle rapidly narrowed.Aluko was emerging as Chelsea’s biggest threat and she then forced Telford to fist away her swerving shot after robbing England team-mate Laura Bassett and skipping in from the left.The Lady Pies had no answer to Aluko’s pace and Chelsea should have been 1-0 up when her centre was somehow hooked back across the face of goal and wide by Gemma Davison inside the six-yard box.However, moments later Aluko was instrumental in giving the Blues the lead.Once more she drove in from the left and shuffled a pass inside from the incoming Ji. Although the South Korean’s touch appeared to have prevented a clear shot at Telford’s goal, a fortunate ricochet into her path allowed Ji to prod in a 37th-minute opener.Notts County’s best spell came during back-to-back corners early in the second half, with Desiree Scott almost equalising on the hour.She took a half-cleared corner down brilliantly on her instep before firing a sweetly-struck half volley which Gilly Flaherty’s head deflected narrowly past a post.From the resulting corner, Davison was needed on the back post to smash away a Leanne Crichton header that would have crept in the bottom corner.Chelsea then had a glorious chance to wrap it up with 17 minutes remaining, yet an unmarked Flaherty stabbed over from close range after Aluko’s clever flick found her six yards out.But Ji’s goal proved enough as the Blues held on for a richly-deserved triumph in front of a national television audience. 1last_img read more

first_imgMay 15 2018The seemingly unrelated conditions of hypertension, epilepsy and overactive bladder may be linked by electrical activity in a protein long studied by a biomedical engineer at Washington University in St. Louis.After new technology recently revealed the structure of the protein, the lab of Jianmin Cui, professor of biomedical engineering in the School of Engineering & Applied Science, will collaborate with two others to take an unprecedented look into its molecular mechanisms potentially leading to the development of new drugs for these and other conditions.Cui has received a four-year, $2.9 million grant from the National Institutes of Health to study the BK (big potassium) channel proteins in collaboration with labs from the University of Missouri-Columbia and the University of Massachusetts. The labs will each play a role in identifying new compounds that could go into the drug development pipeline.Cells have ion channels across the cell membrane, which are pathways that conduct electrical currents into or out of the cell and open in response to physical signals, such as voltage, or chemical signals, such as calcium ions. But these channels typically allow only one type of ion to pass through, for example, the BK channel only allows potassium to pass through.Recently, another lab used a new, Nobel-Prize-winning method called cryo-electron microscopy that allowed them to see the structure of the BK channel, which has given Cui’s lab a fresh look at the channel’s mechanisms. While researchers already knew the channel has three different domains -; the voltage-sensing domain, the cytosolic domain and the pore domain-; they do not know how sensors in other domains open the gate in the pore domain. Cui’s lab seeks to find that pathway.”In BK channel, the question is how would calcium binding in the cytosolic domain open the pore in the transmembrane pore domain,” Cui said. “We have the structural information, but the structure itself cannot answer the question of how the two domains will interact to propagate and transfer the movements in calcium binding that causes the cytosolic domain to open.”Related StoriesMother calls for protein shake regulation after daughter diesQuorn protein stimulates muscle building to a greater extent than milk proteinScientists discover hundreds of protein-pairs through coevolution studyTo answer the question, a lab at the University of Missouri-Columbia will identify chemical compounds that would bind and modify the channel protein to probe the parts of the channel protein that move upon calcium binding. They will pick out those compounds from a library of about a quarter of a million chemicals with known structures stored in computers. They will compare the structures of these chemicals one by one to potential sites in the channel protein using computers in an operation called docking, which may identify a handful of chemical compounds that might bind to the channel protein. Then they will apply the real compound of these hits from the in silico (in computer) screening to treat BK channels in cells and test if they modify channel function.At the University of Massachusetts, a team will simulate the motion of part of the protein to see if those motions are important in propagating the calcium-binding-induced movements to the pore.Finally, Cui’s lab will study the function of the channels by recording ionic currents flowing through these channels. These recordings, in combination with mutating the channel protein and some molecular modeling, will allow the lab to determine if the changes they see in the experiments and in simulation are factors for propagation.”We want to know where the structure changes, how does it change and what makes it change,” Cui said. “These understandings, along with the identification of compounds and their binding sites, could lead to the development of drugs for treating BK channel-related diseases.” Source:https://source.wustl.edu/2018/05/an-unprecedented-look-into-the-protein-behind-hypertension-epilepsy-and-other-conditions/last_img read more