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first_imgA Downing Street spokesperson said: The Prime Minister jointly hosted the inaugural meeting of the UK-Saudi Arabia Strategic Partnership Council with the Crown Prince of Saudi Arabia, Mohammed bin Salman, at Downing Street earlier today. The meeting agreed a landmark ambition for around £65bn of mutual trade and investment opportunities over the coming years, including direct investment in the UK and new Saudi public procurement with UK companies. This is a significant boost for UK prosperity and a clear demonstration of the strong international confidence in our economy as we prepare to leave the European Union. These new investment and procurement opportunities will be spread across a range of sectors including education, training and skills, financial and investment services, culture and entertainment, healthcare services and life sciences, technology and renewable energy and the defence industry. The Prime Minister said the UK was a firm supporter of Saudi Arabia’s ‘Vision 2030’, an ambitious blueprint for internal reform that aims to create a thriving economy and a vibrant society – conditions that we agree are essential to the Kingdom’s long-term stability and success. She noted that as a world leader across a range of sectors, the UK was uniquely placed to partner Saudi Arabia in delivering these vital reforms. The Prime Minister welcomed recent reforms in Saudi Arabia, including on women attending sporting events and the cinema, and being legally able to drive from June. The Prime Minister and Crown Prince agreed that we should continue working together to explore ways the UK can support Saudi Arabia to progress and intensify these reforms, particularly on women’s rights, and on universal human rights, where the Prime Minister noted our particular concerns in the case of Raif Badawi. The Prime Minister and the Crown Prince agreed a new education partnership which will see UK experts help the Saudi education system implement their ambitious domestic reform programme, increasing levels of female participation and boosting inclusivity. This will include UK experts undertaking a comprehensive analysis of the Saudi education system, and sharing best practice and recommendations for modernisation. We will embed gender equality, equal access and equal treatment in all aspects of our programme of support. Following the meeting of the Strategic Partnership Council, the Prime Minister and the Crown Prince received a briefing from UK national security officials on foreign policy issues, including Yemen. The Prime Minister raised our deep concerns at the humanitarian situation in Yemen. The Prime Minister and Crown Prince agreed on the importance of full and unfettered humanitarian and commercial access, including through the ports, and that a political solution was ultimately the only way to end the conflict and humanitarian suffering in Yemen. They also discussed Iran, agreeing on the importance of working together to counter Iran’s destabilising regional activity, and Iraq, including the importance of supporting reconstruction efforts.last_img read more

first_imgEver since his ever-unfortunate passing, the music scene has honored Prince with countless cover songs, concert tributes, and even in a second line down the streets of New Orleans. His discography is one that will last forever, as the Purple One’s music resonates as some of the best pop music to date. When a musician dies, their fans mourn the ending of an era. How can one live without more music from Prince?My Morning Jacket Brings Out Pres Hall Horns For Prince Tribute At Jazz Fest [Watch]Fortunately, a vault containing unreleased Prince songs was drilled open, according to ABC News, and the findings are enough to last another lifetime, and beyond. Bremer Trust, the St. Cloud, Minnesota, company was given temporary authority over Prince’s Paisley Park estate. Upon knowing the contents within, they were forced to drill open the vault because only the Purple One knew the code. “One day, someone will release them. I don’t know that I’ll get to release them,” Prince told “The View” back in 2012. “There’s just so many.” There’s reportedly enough music to release an album every decade for the next century. Susan Rogers, Prince’s former recording engineer, told “Good Morning America” that they “could put out more work in a month than most people could do in a year or more.” She also told The Guardian, that when she left in 1987, “it was nearly full. Row after row of everything we’d done. I can’t imagine what they’ve done since then.”Trey Anastasio Talks About The Night Phish Partied With Prince At Paisley ParkApparently the vault is a giant room in Prince’s Paisley Park with shelves that filled up with music very quickly. The door was sealed with a large purple spinning wheel and held the contents of Prince’s entire working career. So the question, now, is… When can we listen?With Prince having left no will, his family is currently fighting over the contents of his life. Where will this massive collection of unreleased Prince music go?[photo via CoS]last_img read more

first_imgTwo fruit flies meet in an acrylic mating chamber and check each other out. It’s the insect version of speed dating for science.The male taps the female with his leg, which is studded with pheromone-sensing receptors. He then might doggedly follow her around and serenade her with a song by sticking out a wing and vibrating it. But before the male engages in this courtship ritual, he needs to make an important decision: Should he put the moves on this female or not?In a study published online July 5 in Neuron, scientists at Harvard Medical School (HMS) show that what tips the balance in favor of or against is a convergence of motivation, perception, and chance. The combination, the researchers found, powerfully influences the balance of excitatory and inhibitory inputs to a small region of the brain.It’s not about sexUnderstanding the mechanisms of insect choice, the research team said, could help scientists glean insights into and develop strategies for the treatment of human disorders where motivation goes awry, such as addiction and depression.For study authors Dragana Rogulja, assistant professor of neurobiology at HMS, and Michael Crickmore, assistant professor of neurology at HMS and the F.M. Kirby Neurobiology Center at Boston Children’s Hospital, helping unravel the neurobiology behind such abnormalities in human motivation is the ultimate quest. However, their explorations take place in the insect brain’s motivation circuitry — the interconnected sets of neurons that fruit flies use to choose whether to do things like eat, sleep, or mate.Fruit fly courtship is an ideal model to study this fascinating circuitry, explained Rogulja, because the anatomy that governs this phenomenon is relatively simple and sexually dimorphic in these insects, which makes it easy to locate and manipulate. A group of about 20 neurons, called P1, functions as the male fly’s courtship command center.The team’s research shows that when male fruit flies give females a leg tap, the likelihood of initiating courtship is based on two factors: the males’ internal state — their libido or how amorous they feel — and on external stimuli, such as the “quality” of their mating target.For example, males who haven’t mated in a while will initiate courtship about 44 percent of the time following each leg tap of a female that is sexually mature and also hasn’t mated in a while. That number drops to about 7 percent if presented with a female who has recently mated, and to about 6.5 percent if the male has engaged in a lot of recent mating himself.Based on previous work in their laboratories, Rogulja and Crickmore knew that dopamine — a brain chemical that guides desire and motivation in flies and humans alike — is a catalyst in fly mating, and that dopamine levels are high in sex-starved male flies. But the neural mechanisms by which this chemical signal directs courtship behavior were unknown.Inside the male (fruit fly) mindTo better understand what motivates courtship in male flies, the researchers used a combination of different methods, including a technique that makes neurons light up under the microscope, deleting particular receptors from the surfaces of other neurons, and using light to stimulate or inhibit populations of neurons.Together, their results paint a picture of what’s happening inside the male fly brain.After that initial leg tap, the researchers explained, a flood of both excitatory (“Go for it!”) and inhibitory (“Don’t bother”) signals flow into the courtship command center, the P1. If the male’s target is perceived as “low quality” — not sexually mature, too young, too old, or if his pheromone receptors detect a low level of sexual desire in her — the P1 center will receive more inhibitory than excitatory signals.However, according to Rogulja, if the male fly’s P1 neurons receive a lot of dopamine, they become less sensitive to the inhibitory signals, giving the male fly the go-ahead to court, sometimes even under circumstances that aren’t ideal. The circuits underlying the decision to pursue someone or something, however, may incorporate an element of chance, rendering these generally logical behaviors occasionally quirky and even irrational. After the initial decision to court, dopamine is also responsible for maintaining courtship behavior all the way until mating, she explained. Flies with low levels of dopamine might make a half-hearted attempt at courting but quickly give up.However, those with high levels of dopamine are likelier to persistently pursue their love interests.“Dopamine tells the command center how to respond initially and when to give up,” Rogulja said. “The decision to court is a function of these neurons.”It’s complicatedHowever, noted Crickmore, the male flies didn’t act reflexively — even highly motivated males paired with ideal females didn’t court after every tap. They did so only 44 percent of the time. Similarly, males with low motivation because of recent mating or a less-than-ideal target still courted occasionally. This binary decision to court or not court, he explained, has an element of chance, like a coin toss, weighted by factors including the male’s motivation and the sensory information he receives from the female.That element of chance is a key part of what makes the brain’s motivation circuitry different from the circuitry responsible for processing sensory or motor signals.“When you cross the street, you want to be able to see a car coming toward you with 100 percent certainty,” said Crickmore. “When you’re walking, you want your right leg to follow your left leg 100 percent of the time. You don’t want things left up to chance.”The circuits underlying the decision to pursue someone or something, however, may incorporate an element of chance, rendering these generally logical behaviors occasionally quirky and even irrational.In future studies, Crickmore and Rogulja want to understand better how chance is integrated into motivational circuits by identifying the responsible genes and circuit principles.Importantly, the scientists said, the neurobiology and neurochemistry of fruit fly motivation might bring about valuable insights into what goes awry in addiction, in which individuals are propelled toward substances or activities that can be harmful, or in depression, where it’s hard for people to summon up motivation even for the normal activities of daily life.“When you think about it this way, these conditions lock individuals on the wrong end of the probability distribution,” Crickmore said. “Doing productive things too rarely or engaging in destructive behaviors too often.”Historically, the researchers said, discoveries made in the fruit fly model have translated well into insights about humans — evidenced most recently in last year’s Nobel Prize for elucidating the molecular mechanisms of circadian rhythms.Additional authors include Stephen Zhang, Lauren Miner, and Christine Boutros.This work was supported by the New York Stem Cell Foundation.last_img read more

first_imgVan Fossen emphasized the scenarios and numbers are just potential at this point. But despite the possible financial hardships, he and the district are dedicated to being there for students. “It’s all on the table when it comes to these types of reductions potentially, ” he said. To view the a statement by Van Fossen to the MECSD community, click here. “We would be looking at $5.6 million state aid loss for that period of time,” Van Fossen said. “You could argue it’s on the brink of significant devastation if we don’t figure out how to fund schools and try to mitigate this current issue that we are facing right now.” The district currently has reserve funds to use for the next month and a half, and Van Fossen is closely monitoring decisions made in congress to help public schools across the country who face a similar crisis. Van Fossen says the district relies on state aid to make up for half of its budget, and if the reduction becomes a reality, activities like extracurriculars, elective programming and even athletics could be some elements to go. ENDWELL (WBNG) — The Maine-Endwell Central School District could be facing financial devastation as the school may lose out on state funding this year.center_img Governor Andrew Cuomo announced back in March that because of the economic stress put on the state by the coronavirus pandemic, schools could see their state aid cut by 20 percent. “The problem is that it’s not just Maine-Endwell,’ Van Fossen said. “It’s 700 school districts across the state that are looking at the same issue.” While nothing is confirmed as of Aug. 31, MECSD says this possible reduction could mean quite the significant impact for the 2020-21 school year. “If we’re looking at what’s good for society, what’s good for kids, you need a public education system,” Van Fossen said. “Our goal will be to try and continue to provide the best education you can.” “I don’t want to be dramatic, but to use the word ‘catastrophic,’ I’m not saying that lightly,” said superintendent Jason Van Fossen.last_img read more

first_imgA drop in childhood vaccinations in the North-West has led to an increase in the risk of measles and meningitis outbreaks rises.The HSE has warned that the uptake of routine childhood vaccinations has dropped at the start of 2019 with only 85% of two-year-olds in Donegal receiving the MMR vaccine.The uptake of 2 doses of the meningitis C vaccine was 76% for Donegal and 85% for Sligo/Leitrim. Full protection with 3 doses of the pneumococcal vaccine (PCV) was also low at 75% for Donegal and 85% for Sligo/Leitrim.The pneumococcal vaccine protects against a number of serious diseases such as pneumonia, meningitis and septicaemia.Although the majority of people in Donegal, Sligo and Leitrim are still protecting their children with vaccination, 95% of people need to have the MMR vaccine to prevent the spread of measles.The current vaccination levels in the North West will not stop outbreaks of disease, warned the HSE. So far in 2019, there have been have had 12 cases of measles, 7 cases of whooping cough and 169 cases of mumps in the North West.Dr Laura Heavey, Specialist Registrar in Public Health Medicine in HSE North West said it is vital that parents take children to be vaccinated.She said “Every parent wants to protect their child and do what’s right for them. Sometimes it can be difficult to know what to do, now that there is so much false and misleading information on the internet and social media when it comes to vaccination.‘I would really encourage parents to look for information in the right places. Two good sources of reliable, evidence-based information are www.immunisation.ie and the Vaccine Knowledge Project at http://vk.ovg.ox.ac.uk/.“All of the vaccines on the infant, child and adolescent schedule in Ireland are backed up with years of data on their safety.’ A HSE spokesperson said that when vaccination rates fall, they immediately see in an increase in cases of diseases like measles, whooping cough, pneumonia and meningitis.The spokesperson warned “These diseases can result in serious illness and even death. Even those who survive can have long term impacts on their health.“Infection with the measles virus wipes out the special white blood cells, called T lymphocytes, that play a vital role in immunity to disease.“This means that children who get infected with measles will go on to get more illnesses for up to 3 years after their measles infection resolves, as their immune system struggles to recover from the virus.” Dr Heavey added that getting a disease ‘naturally’ is actually more risky for a child’s immune system.‘A vaccine contains bacteria or viruses that are weakened or killed. Vaccines don’t activate the immune system in the same way that getting infected with a live bacteria or virus would.“It’s much, much safer to get the MMR vaccine, for example, than risk your child getting sick with the live measles virus. A live virus or bacteria is much more stressful and difficult for the immune system to deal with’.The HSE spokesperson added “Vaccines save up to 3 million lives every year. New developments mean that vaccines could eliminate certain cancers caused by the HPV virus too. Rising vaccine hesitancy is a serious threat to this progress. False information about vaccines on the internet is one of the causes.“It’s never too late to catch up on your child’s vaccinations. If you are behind the schedule, contact your GP to discuss catching up.”Concerns as drop in vaccinations in North-West leads to risk of outbreaks was last modified: September 23rd, 2019 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

first_imgSAN FRANCISCO–As their second straight losing season comes to a close, the Giants don’t have any plans to perform an autopsy.The ownership group has already mourned the end of the franchise’s golden era. The Giants plan to embrace the next generation, and in doing so, they’ll leave behind general manager Bobby Evans, a key pillar of their glory days.Giants CEO Larry Baer announced Evans was dismissed from his role Monday as part of a wide-reaching organizational shakeup expected to continue …last_img read more

first_imgIt has been an eventful year for veteran Bay Area sportscaster Greg Papa.In January, he became the new radio play-by-play announcer for the San Francisco 49ers — a role he never envisioned while holding the same job for the Raiders from 1997 through the 2017 season.Then, last month, he gave up his noon-time sports talk show on KMGZ (95.7 FM — The game) and jumped to KNBR (680-AM), the 49ers flagship station. Beginning Tuesday, July 16, Papa will reunite with his previous KMGZ on-air partner, …last_img read more

first_imgShare Facebook Twitter Google + LinkedIn Pinterest The May 2015 Miami East-MVCTC FFA Members of the Month are Casey Copeland, Madeline Davis, Olivia Edgell, and Riann Kingrey. They are all retired chapter officers and will soon be graduates of Miami East High School.Casey is the daughter of Rick and Stephanie Copeland of Casstown. She participated in Food Science and Horse Judging Career Development Events. She plans on attending The Ohio State University to major in molecular genetics.Madeline Davis is the daughter of Jerry and Noelle Davis of Troy. She was a Start State in Agribusiness Finalist and National Proficiency Finalist. She plans on attending Randolph College to major in business and equine science where she will be a member of the equestrian team.Olivia Edgell is daughter of Brian and Jamie Edgell of Fletcher. She served as chapter President and attended the Washington Leadership Conference. She plans to attend Walsh University where she will play college softball and major in early childhood education.Riann Kingrey is the daughter of Brad and Tanya Kingrey of Fletcher. She earned her State FFA Degree and coordinated the chapter’s trap-shooting events. She will attend Wright State University and major in computer science.Every month of the school year the Miami East-MVCTC FFA will select a student to be the FFA Member of the Month.  The officer team will nominate one student that has been actively involved in the FFA chapter, school and community activities.  If selected, the member will be recognized at the monthly FFA meeting, have their picture displayed in the Miami East Agricultural Education Room, and will receive a special medallion on celebration of their accomplishment.last_img read more

first_imgJason Liles explains how he successfully played George the Gorilla in ‘Rampage’ Updated: 11:51 AM 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – Preparing for a role in a play or film can be very tedious because the actor must focus on the most minute details of the character that they’re trying to portray.But preparation for Jason Liles’ role as George the Gorilla in ‘Rampage’ was just as rigorous as any other role.Jason Liles was here to tell us how he successfully played the role and received praise from other actors in the industry.“Rampage is massive, ‘Rampage’ is fun, but the one thing that ‘Rampage’ is about more than anything is the relationship I have with my best friend, ‘George,’ played absolutely brilliantly and to perfection by Jason Liles.” — Dwayne “The Rock” Johnson on Jimmy Kimmel Categories: Good Morning San Diego, Local San Diego News FacebookTwitter Lauren Phinney, KUSI Newsroom center_img July 19, 2018 Lauren Phinney, KUSI Newsroom, Posted: July 19, 2018last_img read more

first_img Updated: 10:36 PM Ashlie Rodriguez, Posted: October 29, 2018 Thousands honor Pittsburgh synagogue victims at community vigil October 29, 2018 Categories: Local San Diego News, National & International News FacebookTwitter 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsLA JOLLA (KUSI) – Thousands poured into congregation Beth Israel tonight to pay tribute to the eleven victims of the Pittsburgh synagogue shooting.Their presence, a massive show of solidarity against hate here in San Diego.KUSI’s Ashlie Rodriguez was live Monday evening at UTC with more. RELATED: Synagogue massacre defendant appears in court in wheelchair Ashlie Rodriguez last_img read more