Tag: 上海夜网HJ

first_imgAcute leukaemia has a high relapse rateScientists are working on a way to stop one of the most aggressive forms of acute leukaemia, MLL, returning after a patient has received treatment.Recurrence of the blood cancer caused by rogue leukaemic stem cells is a major problem for doctors.But a team at King’s College London, working on mice, have raised hopes of a solution.They describe in the journal Cell Stem Cell how they eliminated the stem cells by suppressing two key proteins.It is hoped the work, funded by Cancer Research UK and Leukaemia Lymphoma Research, will lead to new treatments which will enable complete remission for patients with a form of acute leukaemia.Cancer stem cells appear to be more resistant than other leukaemia cells to standard treatments, such as radiotherapy and chemotherapy.So even after treatment appears to have been initially successful, they can remain to trigger a new round of disease, which often reappears in a more aggressive form.More than 50% of acute leukaemia patients will relapse and survival is poor, with fewer than half living for five years.The King’s team looked at leukaemic stem cells found in a type of acute leukaemia involving mutations in a gene called MLL.This particularly aggressive form of the disease accounts for about 70% of infant leukaemias, and 10% of adult acute leukaemias.Only half of children diagnosed with the disease survive for two years after receiving standard treatment.Double assaultA protein called Bmi1 was already known to play a key role in the survival and proliferation of various cancer stem cells.But the King’s team showed that targeting Bmi1 alone was not enough to eradicate the rogue stem cells, as had previously been thought. To do that, the scientists found that Bmi1 had to be targeted in harness with a second protein, Hoxa9.This double assault abolished the ability of MLL mutation to induce leukaemia.Researcher Professor Eric So said: “These findings take us a step forward in our understanding of how this devastating disease can return in patients after they have received the standard treatment.“Now we know that leukaemic stem cells in certain types of leukaemia, such as MLL, can survive and proliferate independently of the Bmi1 protein, we need to consider more carefully the future of stem cell therapy to treat the disease.“It’s not as easy as people originally thought it might be.”Professor So said the next step would be to pin down exactly how the two proteins help cancer cells to grow.Professor Peter Johnson, Cancer Research UK’s chief clinician, said: “Cancer stem cells appear to be more resistant to radiotherapy and chemotherapy than the other leukaemia cells, so understanding how they originate – and how we can kill them – will be a major step in being able to help even more people survive leukaemia in future.”Dr David Grant, scientific director of Leukaemia & Lymphoma Research, said: “It is now widely agreed that leukaemia stem cells are the true target for new or existing drugs if patients are to be cured.“This research is important in uncovering how leukaemia stem cells are controlled at the genetic level which in turn will guide new treatments to tackle this difficult problem.”BBC News Share HealthLifestyle Hopes raised of blocking return of leukaemia by: – June 4, 2011 Share Sharing is caring!center_img Share 15 Views   no discussions Tweetlast_img read more

first_img Published on April 27, 2011 at 12:00 pm Facebook Twitter Google+ Lindsay Rogers sat on a cooler on the sideline watching her teammates beat Cornell 13-9 Tuesday. She wore her jersey with the number 50 on her back, but instead of her uniform skirt, she wore orange shorts. Instead of her mask, she sported a Syracuse baseball cap.Her elbows rested on her knees as she leaned forward on her cooler to see the action on the field. When the ball ventured into Syracuse’s defensive end, she raised her head up an extra 45 degrees and shouted advice to her fellow defenders and to SU goaltender Liz Hogan.Rogers has missed the past five games after reinjuring her knee against Connecticut. And with the key piece of the defense gone, SU head coach Gary Gait and his team have had to adapt.‘She provides so much leadership that it’s unfortunate that we don’t have that,’ Gait said. ‘But she still gives us some from the sideline, and that’s been great.’With Rogers absent, the defense has had to find new ways to compensate for her leadership and communication skills. And the unit has done just that. Since Roger’s injury, the Orange is 4-1, the loss coming to No. 17 Georgetown. The other four games were against unranked opponents. On Friday, when the Orange (8-7, 5-1 Big East) travels to play No. 5 Loyola (13-1, 5-1) at 7 p.m., the defense will face its toughest test yet without Rogers.AdvertisementThis is placeholder textAs the leader of the defense, Rogers provided support for the other defenders. The defenders look up to her for leadership on the field, asking her about slides and covering cutters, said junior defender Janelle Stegeland. Just getting an occasional call from the sideline has been hard, she said.‘I’m always asking her questions,’ Stegeland said. ‘… I think that’s a little more difficult to not have someone right on the field with you.’Rogers also served to organize the defense. She was the chief communicator in the back, setting up the defense and making sure every opponent was covered. In Rogers’ first game out, Hogan stepped up to help with communication. The keeper came up big for her team with 11 saves. She earned Big East Defensive Player of the Week for her performance in the weekend’s games.Over the past four games, however, the defense has had to find a balance. Whether it’s communicating or making the big plays, Hogan said everyone on defense has contributed.‘She’s the communicator on defense,’ Stegeland said. ‘She’s always the one talking. She’s always the one directing … Between Liz and all the defense we’ve really filled that, but I think Liz has been a great part of that.’The Orange defense without Rogers will face its biggest challenge yet Friday. Loyola averages the most goals per game in the Big East at 14.21. They are led by senior attack Grace Gavin, who has had one of the best offensive seasons in the conference. She leads the league with just fewer than 5 points per game.Last season, Loyola was not as renowned because it lacked senior leadership. This year, however, Gait said that will help Greyhounds.‘Their team pretty much stayed intact from what it was last year, so that’s been their advantages this year — that they’ve had more experience than a lot of the other teams especially in the Big East,’ Gait said. ‘It’s propelled them from kind of the middle of the pack to the top.’Loyola and Syracuse are currently tied for second in the Big East each with two games left to play. Rogers is working her way back, and although she will definitely be on the bench for Friday’s game, she is expected back before the tournament.So without her, Syracuse will have to continue to put together a joint effort to fill the spot she has left behind.‘They’re not going to exactly be the leader that she was,’ Hogan said. ‘But at the same time, if everyone gives a little bit more, it kind of makes up for it.’[email protected]center_img Commentslast_img read more

first_imgDeja Bron.Yes, we’ve been here before … annually for four years … with LeBron James in the NBA Finals against the Warriors, who won two of the previous meetings and led the third 3-1 before LeBron led the Cavaliers in their historic rally to win the 2016 title.We’re off to a thrilling, almost shocking start with the Warriors in predictable post-Rockets lethargy and the Cavs blowing Game 1 before losing in overtime. I’d still put the over-under on Cleveland wins at one, in which case the Cavs can try to rally from 3-1 down again.A lot changed in a week and it’s not good news in Lakerdom. AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREUCLA alum Kenny Clark signs four-year contract extension with PackersThe Warriors looked set to fall with the Rockets about to go up 3-2 when Chris Paul, who had scored nine of his 20 points in the fourth quarter, missed a turnaround in the lane and fell awkwardly with 51 seconds left in Game 5.Signaling he was really hurt, he didn’t get up and run back to play defense. (The Warriors didn’t score with Quinn Cook missing an open 3-point attempt.)That ended Paul’s season and, ultimately, Houston’s. The Rockets who opened double-digit leads in Games 6 and 7 but burned out and were run over in both with Coach Mike D’Antoni’s already short playoff rotations down a man they couldn’t afford to lose.More fans than Houston’s winced at the sight of CP3 limping, including those in Lakerdom.The Lakers’ anticipated pursuit of James and Paul George always depended on a number of things happening, which seemed to be thisclose to coming true. Their young team had shown promise. LeBron and George appeared to have no better options. VIDEO: Watch Kyle Kuzma’s game winner and what he said about it George’s Thunder had lost in the first round with Carmelo Anthony disappearing, showing the PG-Melo-Russell Westbrook combination didn’t work.LeBron’s Cavaliers had to rally from 3-2 to beat the young Celtics without Kyrie Irving. Showing how little that impressed anyone, the Cavs then became historic Finals underdogs with VegasInsider.com listing them at 10-1 meaning Warriors bettors had to put up $10 to win $1.Had the Rockets won a title, they still would have pursued James but not with their current desperation after falling short yet again … which is necessary since they’d have to dump most of their players.For his part, LeBron would have been leery about the way joining a title winner would have looked. Kevin Durant is still being sneered at for joining the Warriors and they were coming off their 2016 Finals loss to the Cavaliers.What had only been speculated upon is now happening … or being speculated on so much, it might as well be happening … after the New York Times’ Marc Stein assured a questioner on Twitter that “Paul has already begun his recruitment of James.”Speculative as it was, it’s safe to assume. James and CP3 aren’t just close, they’re best buddies with Paul the godfather to LeBron’s oldest child, LeBron Jr.Moreover, that means something to James. LeBron, CP3 and Melo have talked throughout their careers about their desire to play with each other outside the Olympics if they ever got the chance.Nor will it bother James to be in a second-tier market like Houston, rather than a glamor capital like Los Angeles. If the best players usually want the brightest lights and the biggest stage, LeBron is 180 degrees different. It has always been a personal conceit that wherever he is is a marquee market. He wasn’t even 21 as a young NBA player when he began convening an annual marketing conference – in his hometown of Akron, not even nearby Cleveland – obliging his sponsors to show up there.It’s true that LeBron owns two pricey homes in Brentwood, suggesting that he is, indeed, thinking about the Lakers … but that might mean little in the end.“These days it doesn’t matter because you can be known and be a star from anywhere – anywhere in the world,” Maverick Carter, LeBron’s point man, recently told syndicated talk show host Rich Eisen.“I mean, could he sell a few more sneakers if he was in a gigantic market like Boston, Chicago, New York, or L.A.? Maybe. But not as much as if he wins. What matters the most is if he wins. When you win as an athlete, that matters the most.”Sign up for Home Turf and get 3 exclusive stories every SoCal sports fan must read, sent daily. Subscribe here.In the end, it will depend on what feels right to James.The Rockets would have to move everybody except Paul, James Harden, Clint Capela, Trevor Ariza and Ryan Anderson to clear enough cap space.(They could keep Eric Gordon and P.J. Tucker if they can find a taker for Anderson, the stretch four who fell into disuse, but with two years and $41 million left on his contract, it remains to be seen if GM Daryl Morey can pull that off.)Who knows?Maybe LeBron would prefer to be The Man, as he always has been, with George and the young Lakers, rather than a big piece in an ensemble cast on a team in a town that has always belonged to Harden.Dwyane Wade manfully moved over for James in Miami, becoming another of his close friends, but LeBron knows how hard situations like that can be. Philadelphia also will reportedly be in the picture, suggesting the 76ers aren’t high on their potential with Markelle Fultz, who’s no longer as universally admired as he was before his lost, injury-filled rookie season.Related Articles Jubilation, anguish as race for NBA’s Western 8th seed gets as close as ever First, the 76ers have to straighten out this story about GM Bryan Colangelo and burner Twitter accounts linked to him, or his wife, that tweeted bad things about 76ers players. Whether or not Colangelo did anything wrong, ESPN’s Adrian Wojnarowski and Zach Lowe speculate that Colenagelo might be fired to eliminate any question … because they intend to pursue LeBron.Of course, you can hear CP3 from here:Don’t worry about it, Bron. We’ll bring in a bunch of minimum salary guys like Mike Miller, who followed you all over the league, to make open shots and rebound. We’ll plow those [email protected]#$% Warriors under and I’ll shimmy in front of Steph Curry until he gets dizzy and falls over.Let’s see, am I forgetting any LeBron suitors?Oh, right, the Cavaliers. They’re still in the Finals, the show before the real show.center_img Lakers on verge of sealing home court advantage, what does it mean in the NBA bubble? Newsroom GuidelinesNews TipsContact UsReport an Error VIDEO: LeBron James and Doc Rivers respond to Donald Trump calling NBA kneeling protests “disgraceful” Morning Wrap: Full coverage from Lakers-Clippers thriller; Angels, Dodgers going in different directions; Whicker pays tribute to legendary Mike Gillespie last_img read more