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first_imgAcute leukaemia has a high relapse rateScientists are working on a way to stop one of the most aggressive forms of acute leukaemia, MLL, returning after a patient has received treatment.Recurrence of the blood cancer caused by rogue leukaemic stem cells is a major problem for doctors.But a team at King’s College London, working on mice, have raised hopes of a solution.They describe in the journal Cell Stem Cell how they eliminated the stem cells by suppressing two key proteins.It is hoped the work, funded by Cancer Research UK and Leukaemia Lymphoma Research, will lead to new treatments which will enable complete remission for patients with a form of acute leukaemia.Cancer stem cells appear to be more resistant than other leukaemia cells to standard treatments, such as radiotherapy and chemotherapy.So even after treatment appears to have been initially successful, they can remain to trigger a new round of disease, which often reappears in a more aggressive form.More than 50% of acute leukaemia patients will relapse and survival is poor, with fewer than half living for five years.The King’s team looked at leukaemic stem cells found in a type of acute leukaemia involving mutations in a gene called MLL.This particularly aggressive form of the disease accounts for about 70% of infant leukaemias, and 10% of adult acute leukaemias.Only half of children diagnosed with the disease survive for two years after receiving standard treatment.Double assaultA protein called Bmi1 was already known to play a key role in the survival and proliferation of various cancer stem cells.But the King’s team showed that targeting Bmi1 alone was not enough to eradicate the rogue stem cells, as had previously been thought. To do that, the scientists found that Bmi1 had to be targeted in harness with a second protein, Hoxa9.This double assault abolished the ability of MLL mutation to induce leukaemia.Researcher Professor Eric So said: “These findings take us a step forward in our understanding of how this devastating disease can return in patients after they have received the standard treatment.“Now we know that leukaemic stem cells in certain types of leukaemia, such as MLL, can survive and proliferate independently of the Bmi1 protein, we need to consider more carefully the future of stem cell therapy to treat the disease.“It’s not as easy as people originally thought it might be.”Professor So said the next step would be to pin down exactly how the two proteins help cancer cells to grow.Professor Peter Johnson, Cancer Research UK’s chief clinician, said: “Cancer stem cells appear to be more resistant to radiotherapy and chemotherapy than the other leukaemia cells, so understanding how they originate – and how we can kill them – will be a major step in being able to help even more people survive leukaemia in future.”Dr David Grant, scientific director of Leukaemia & Lymphoma Research, said: “It is now widely agreed that leukaemia stem cells are the true target for new or existing drugs if patients are to be cured.“This research is important in uncovering how leukaemia stem cells are controlled at the genetic level which in turn will guide new treatments to tackle this difficult problem.”BBC News Share HealthLifestyle Hopes raised of blocking return of leukaemia by: – June 4, 2011 Share Sharing is caring!center_img Share 15 Views   no discussions Tweetlast_img read more

first_imgNew Delhi: Former India captain Sourav Ganguly on Wednesday called for severing all sporting ties with Pakistan in the wake of Pulwama terror attack which left 40 CRPF personnel martyred.Ganguly echoed sentiments of his one-time teammate Harbhajan Singh, saying that not playing Pakistan in one group league tie in the upcoming World Cup will not affect India’s chances.However, Ganguly didn’t elaborate whether the protest should be symbolic for one game or India should forfeit if they happen to meet Pakistan in semi-final or final.“This is a 10-team World Cup and each team plays matches against every other team and I feel if India doesn’t play a match in the World Cup, it won’t be an issue,” Ganguly told India TV.Also Read | Pulwama Terror Attack: Pakistan shooters to not take part in Shooting World Cup“I feel it will be really difficult for ICC to go on with a World Cup without India. But, you also have to see if India has the power to stop ICC from doing such a thing. But, personally I feel a strong message should be sent,” Ganguly added.Ganguly said India should to cut off all ties with the neighbouring country.“And, whatever reactions came from the people of India…was right. There is no chance of a bilateral series with Pakistan after this incident. I agree that after this attack, India should not only stop playing cricket, hockey or football with Pakistan but should cut all ties with them,” Ganguly said. For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps.last_img read more