Tag: 贵族宝贝

first_img Why birds don’t crash Related Since Darwin’s era, scientists have wondered how flightless birds like emus, ostriches, kiwis, cassowaries, and others are related, and for decades the assumption was that they must all share a common ancestor who abandoned the skies for a more grounded life.By the early 2000s, new research using genetic tools upended that story, and instead pointed to the idea that flightlessness evolved many times throughout history. Left unanswered, however, were questions about whether evolution had pulled similar or different genetic levers in each of those independent avian lineages.A team of Harvard researchers believes they may now have part of the answer.Based on an analysis of the genomes of more than a dozen flightless birds, including an extinct moa, a team of researchers led by Tim Sackton, director of bioinformatics for the FAS Informatics Group, and Professor of Organismic and Evolutionary Biology Scott Edwards found that while different species show wide variety in the protein-coding portions of their genomes, they appear to turn to the same regulatory pathways when evolving flight loss. The study is described in a recent paper published in Science.In addition to Sackton and Edwards, the study was co-authored by Jun Liu, professor of statistics and of biostatistics; statistics research assistant Zhirui Hu; Alison Cloutier, a postdoctoral researcher working in Edwards’ lab; Phil Grayson, a graduate student in the Edwards lab; and teams from New Zealand, the University of Texas, Austin, and the Royal Ontario Museum.“There is a long history in evolutionary biology of converging traits — the idea that there’s independent evolution toward the same kind of phenotype,” Sackton said. “What we were interested in is, how does that happen?”Flightless birds all have similar body types, Sackton noted. “They have reduced forelimbs [wings], to different degrees, and they all have this loss of the ‘keel’ in their breastbone that anchors flight muscles,” he said. “What that amounts to is a suite of convergent morphological changes that led to this similar body plan across all these species.”To understand what drove that suite of changes, Sackton, Edwards, and their colleagues turned to the genomes of the birds themselves.“We wanted to compare not just the parts of the genome that code for proteins, but also the parts of the genome that regulate when those proteins are expressed,” Sackton said. To identify those regions in the various species examined for the study, the team used a process that involved aligning the genomes of more than three dozen bird species — both flying and flightless — and then identifying regions that showed relatively few differences in their genetic sequence. These places in the genome that are conserved but are not part of proteins, are likely to have a regulatory function.“We worked with collaborators in Statistics here at Harvard to develop a new statistical method that allowed us to ask, for each of those regulatory elements, how many of these species showed the same pattern of divergence, suggesting they have changed the same regulatory elements,” Sackton said. “And what we found was that while there is not much sharing of protein-coding genes [in general], there is for these regulatory regions, suggesting that there are shared developmental pathways that are repeatedly targeted every time this phenotype has evolved.”While the protein-coding genes appear to be responsible for adaptations in diet, feather function, and environment, Sackton said, the regulatory regions seem to play a key role in the body-scaling changes that go along with flight loss.“What’s interesting about the morphological changes … is they have to preserve their hind limbs,” he said. “There are lots of ways to stop a limb from forming, but shrinking a forelimb without changing the hind limb is more difficult.”And in some ways, Sackton said, that makes sense — strange as it may seem, it is likely easier to simply not form a limb rather than shrink one.“If you think about it, there’s lots of ways to break something,” he said. “There are a bunch of steps early in limb development where, if a protein doesn’t get expressed, it’ll just turn the system off and you don’t get a limb. But this is actually a complicated shift in body scaling. You can’t just willy-nilly grow limbs to different sizes, so … the fact that it’s important they maintain functional hind limbs constrains the system and might be why we see this convergent pattern.”To prove that theory, the team tagged certain regulatory regions in the birds’ genomes with a gene that would produce green fluorescent protein. They found that in flightless species, where those regions were believed to have undergone functional changes, the marker gene was effectively turned off.“To get a limb to start growing, a bunch of things need to happen … so if you can knock out an enhancer and make it harder for those proteins to be expressed you can delay that process,” Sackton said. “This suggests these regions may have lost some important binding sites that prevent them from acting as an enhancer.”What it boils down to, Sackton said, is that birds have a limited number of options to pursue when it comes to the loss of flight, and so various species have gone to the same well again and again.“That’s the conclusion we would draw from this work,” he said. “There are a limited number of ways you can get this type of change in scaling, and they center on this regulation of early limb development.”The study also highlights the power of the multidisciplinary approach taken by Sackton, Edwards, and their colleagues.“One of the things that was exciting about this project for me personally was how we were able to bring the computational expertise in the Informatics Group to bear on this really important question in evolutionary biology,” said Sackton. “This joining of computational, statistical genetics with the natural history perspectives is important for getting the full picture of how these birds evolved.”“It’s exciting what can be done with a research team with diverse skill sets,” Edwards added. “Our group had developmental biologists, computational biologists, morphologists, statisticians, population geneticists — and, of course, ornithologists. Each brings a different perspective and the results, I think, are amazing.”This research was supported with funding from the National Science Foundation and the Natural Sciences and Engineering Research Council of Canada. Brainy birdscenter_img Study shows parrots can pass classic test of intelligence They use just two postures to avoid obstacles during flight, study findslast_img read more

first_imgMilan: Cristiano Ronaldo scored twice as Juventus closed out 2018 on a high with a 2-1 win over Sampdoria to set a new points record in Serie A before the winter break on Saturday. Not to be outdone, however, Napoli’s Arkadiusz Milik also bagged a brace with a 3-2 home win against Bologna to keep the pressure on the champions. Ronaldo-powered Juventus have achieved a record number of points before the three-week winter break with 53 from 19 games. Napoli are nine points behind in second, with Inter Milan a further five adrift in third, days after their clash at the San Siro was overshadowed by the death of a supporter with Napoli defender Kalidou Koulibaly targetted by racist chanting. Koulibaly was suspended for Saturday’s game but fans showed their support in his San Paolo stadium by wearing masks with the defender’s face and holding up banners saying: “We are all Koulibaly”.           Dries Mertens sealed victory two minutes from time after Bologna battled back twice to level Milik’s goals on 15 and 51 minutes. “It was important to end the year on a high and it wasn’t at all easy,” said Juventus coach Massimiliano Allegri after a game in which the video assistant referee played a key role. Two penalties were decided by VAR with Sampordia also having a late equaliser ruled out. Ronaldo curled in the opener after just two minutes in Turin, adding a second from the spot on 65 minutes, to go top of Serie A’s scoring charts on 14 goals. Fabio Quagliarella pulled the Genoa outfit level with a penalty on 33 minutes, before Riccardo Saponara’s late equaliser was ruled offside.          Read More | Liverpool crush Arsenal 5-1 to extend lead in Premier LeagueSampdoria coach Marco Giampaolo, dismissing Ronaldo’s penalty as “a gift,” adding “that Saponara goal should never have been cancelled”. “For me, morally, the game was 2-2.” Read More | Lionel Messi hat-trick boosts Barcelona to top of La Liga tableThe seven-time reigning champions have dropped points just twice, against Genoa in October and Atalanta midweek, and are firmly on track for an eighth consecutive Scudetto. “Records are meaningless, if not to improve and raise the bar,” said Allegri. “We do have the perception that with Cristiano Ronaldo there’s a better chance of winning the Champions League. However, we’re not even in January yet and there’s a very long way to go.”         ‘Extraordinary’ The Portuguese striker found a way through early, picking up a Paulo Dybala cross to fire in past Sampdoria’s on-loan Juventus goalkeeper Emil Audero. Sampdoria pulled level following a penalty awarded following an Emre Can handball with Quagliarella making no mistake. The 35-year-old became the first player to score in nine consecutive Serie A games since David Trezeguet for Juventus in 2005.   Audero deflected over a Ronaldo header on the hour but the hosts went ahead when the referee pointed to the spot for an Alex Ferrari handball. Substitute Saponara looked to have grabbed a point deep into injury time but VAR ruled he was in an offside position. Napoli got back to winning ways after last week’s defeat in Milan, despite missing Koulibaly and Lorenzo Insigne, who were both suspended, and injured captain Marek Hamsik.             Bologna’s Federico Santander and Danilo levelled twice with headers before Mertens secured the win with a powerful drive from a distance. “We’re on track with expectations,” said Napoli coach Carlo Ancelotti. “We had some good results that have only been watered down by an extraordinary Juventus run.”  Earlier Inter Milan earned back-to-back wins with Senegalese winger Keita Balde scoring on 72 minutes in a game played without their fans after the racist abuse aimed at Koulibaly in the San Siro. “It was fundamental that we win this match,” said coach Luciano Spalletti.  Roma profitted from Sampdoria’s defeat to move up to fifth thanks to second half goals for Bryan Cristante (58) and Cengiz Under (75) in a 2-0 win over Parma. Lazio were held 1-1 by Torino in the Stadio Olimpico, as Atalanta beat Sassuolo 6-2 with Slovenian Josip Ilicic scoring a second-half hat-trick. The battle for European football is tight with just six points between Lazio in fourth and Fiorentina in tenth position. Meanwhile, bottom club Chievo achieved their first top flight success with a 1-0 win over fellow strugglers Frosinone. For all the Latest Sports News News, Football News News, Download News Nation Android and iOS Mobile Apps.last_img read more

first_imgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisGovernor Gretchen Whitmer has made a proclamation that will help cancer patients in Michigan. The governor declared April 18–24 cleaning for a reason week so people with the disease can get help at home.Tara Stone, owner of Your Girl Friday LLC received the proclamation from Governor Whitimer, and is already springing into action.“We just received a proclamation from the mayor of Alpena as well as the governor of Michigan declaring April 18th through the 24th national cleaning for a reason week.”Stone says, for her, acknowledgement of this week hits close to home.“Six years ago my aging parents were having issues in their own health, you know, trying to help them with things in and around the house. Two years ago I started my business and it’s grown really well and we partnered with cleaning for a reason and I feel it’s very important. We do have family that has survived cancer and I know what its like, you know, seeing them go through cancer treatments and stuff like that. ”If you or a loved one needs services, Stone says don’t hesitate to reach out. You can visit her Facebook page, Your Girl Friday LLC, or visit cleaningforareason.org.AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThis Tags: Cancer, Cleaning, cleaning for a reason, Tara, Tara StoneContinue ReadingPrevious Alpena native performing two nights of music this weekendNext Alpena Post weekly calls for servicelast_img read more

first_imgBy Chris Rotolo |SHREWSBURY – Can we do more to impact the community in a positive way?This is the question David Levy posed when he accepted the role of president at the Guild of Creative Arts (GCA), as he considered how the 58-year-old nonprofit artist cooperative at 620 Broad St. could influence and extend its reach.For Levy, the GCA was more than a celebrated showroom or heralded hub of creativity for local artists developing ideas.The facility presented Levy a platform, and what’s more, an opportunity, to make the artistic experience accessible to all who sought it, a notion that led him to establish The Docent Program.“Our mission at the Guild is to advance excellence in the visual arts, but our vision is to reach out to everyone in our community, especially the underserved populace, including those with disabilities, and ignite or rekindle their love of art,” Levy said on Tuesday, while prepping the GCA’s Feb. 11 reception for its current Exhibiting and Associate Show, an exhibition that runs until Feb. 27 and features the work of the cooperative’s most prominent artists.According to Levy, The Docent Program, which focuses on the observation of art pieces and emphasizes analysis, evaluation and higher-order thinking skills, caters to the developmental and cognitive needs of elementary school-aged students, as well as children and adults with special needs and senior citizens with cognitive or physical disabilities.Since founding The Docent Program in 2013, Levy has witnessed firsthand the benefits such an offering can provide to the surrounding special needs community, which is why he finds it troubling that funding for the arts has come under fire in recent years.“Art is for everyone and is something that enriches lives,” said Levy, a former college professor of art history, as well as an instructor of gifted and talented students and an enrichment teacher for students with special needs.“There are so many reasons why it’s worthwhile, and for kids especially, it shows that art activities stimulate various parts of their developing brain, which positively impacts other subject areas and aspects of their lives,” said Levy. “The arts are something worth fighting for.”While he remains steadfast in his fight for the preservation of arts education, Levy’s Docent Program continues to offer insight to those who wish to appreciate and interpret art pieces from the perspective of an artist, helping viewers gain a greater understanding of the creatives’ methods and what they hope to accomplish stylistically and affectively.“It was a goal of mine to help transform this into something more than a place to view art and take classes,” Levy said. “We wanted The Guild to be a community resource that could reach out and educate everyone. And this program is helping us do that.”This article was first published in the Feb. 8-15, 2018 print edition of The Two River Times.last_img read more

first_img“That’s the number one for our special projects,” she said.The wallpaper and ceiling upgrades will cost an estimated $6,800 each. Thegroup will also replace four antique cane chairs at Longstreet with hand-wovenseats and also replace some of the heirloom fruit trees at the property. In Colts Neck, the new Sensory Lions’ Den project was recently completed in Dorbrook Park’s Challenger Area, thanks to the Friends of the Monmouth County Park System and the Colts Neck Lions Club. It is designed for people of all abilities, but especially for the visually impaired. In 2020, the group will pay off an additional $2,100 for the playground for additional site work that was not included in the original plan, Wojciechowski said, like extra surfacing areas. “It really looks nice,” she said Dec. 16. MONMOUTH COUNTY – The Friends of the Monmouth County Park System have a lot on their to-do list in 2020. Longstreet Farm, Holmdel Park Photo courtesy MCPS Looking back on 2019, Wojciechowski said it was a very goodyear for the organization, which offers several levels of memberships, startingat $25 for individuals, $50 for families and $250 for corporations. They wereable to raise $281,751 through a membership drive, donations and fundraisingefforts in 2019. “We really had a good year,” she said. Purchasing new fabrics to help repair and createnew historic clothing, $500.Expand social media advertising for park system programsand events, $6,000.Employee training, registration and travel,$10,190.Coastal Activity Center special events, fieldtrips and after-school scholarships for program fees and field trips, $4,550.Therapeutic recreation expenses including asemi-formal, weather presentation, camp scholarships and tickets and entry feesfor inclusion coaches, $3,100.Volunteer Services cards, National Trails Daylunch, gardening tools and holiday reception costs, $2,550. This article originally appeared in the Jan. 9, 2020 print edition of The Two River Times. In a presentation at the Dec. 16 Monmouth County Board of Recreation Commissioners meeting, the Friends charitable organization laid out plans to tackle various projects to fund park system enhancements. One they are particularly excited about is the Nature on theMove project. Nature on the Move will be a $12,000 project to bring crittersto various events in the county, said Maria Wojciechowski, executive directorof the Friends group. Also on the to-do list are essential upgrades to the historicLongstreet Farmhouse in Holmdel. According to Wojciechowski, the farmhouse needsceiling repairs and new wallpaper. The wallpaper work was supposed to be donein 2019, but when they visited the site to replace it, they discovered that theplaster from the ceiling was starting to fall. The park system will purchase a van and the Friends willoutfit it with flat-screen TVs, built-in cabinets and cooling systems toprotect the reptiles and insects on hot days. The Friends will be financing several other events, programs, scholarships and more throughout the year. Here are just a few of the 2020 expenses: “The trees are starting to age out of there, so the parksystem is trying to start to rotate some stock so they don’t all go out at thesame time,” she said. Additionally, cherry trees will be replaced at Holmdel Park.Wojciechowski said she has been told that Monmouth County is home to thesecond-largest display of cherry blossoms in the state of New Jersey. One oftheir goals for 2020 is to replace three cherry trees donated by the Stevensonfamily in town, to maintain the site. The Friends and the park system have various fundraising events throughout the year, but the Friends’ “biggest and newest” event was a wine and craft beer tasting Sept. 19 at Tatum Park. The group raised over $20,000 there, Wojciechowski said. “It really is a lot of fun and my board really works so hard on this. They really put so much effort into it. It really came together nicely,” she added. “It will be kind of like a bookmobile,” said Wojciechowski.“They will be able to take it out on the road to a school program or to afestival or a fair and open it up and have a mini environmental center therethat the naturalists will be able to use.” It will likely take about a year toget everything set up and running.last_img read more

first_imgA man who was abandoned by his friends at a wedding in Letterkenny got into his car after drinking and then crashed it into a roundabout.Letterkenny District Court.Rodney Tighe, 35, had been the designated driver while they were attending a wedding at the Radisson Hotel in the town. However he fell out with his friends and decided to drive.A Garda told Letterkenny District Court that on September 21st last at 2.30am they were on patrol on Pearse Road.They noticed a man taking off at the lights and then he suddenly crashed into an island.He was taken to Letterkenny Garda station and failed a breath test.A taxi-driver also approached Gardai after the crash and said he had witnessed Tighe of 30 Melmount Road, Strabane, driving on the wrong side of the road at Neil T Blaney Road before doing a u-turn.Gardai said 35 year old Tighe was very co-operative when he was brought to the Garda station.The court heard he was a single man with a four year old daughter who earned £70 a week.He was unemployed but had worked as a chef.The court heard that €180 worth of damage had been caused to the roundabout and that Tighe had the money to pay for it in court.Judge Paul Kelly fined Tighe €200 and ordered the money go to the local council and also fined him a further €100 and banned him fro driving for two years on the drink-driving charge.MAN ‘ABANDONED’ BY FRIENDS AT WEDDING CRASHED INTO ROUNDABOUT was last modified: January 21st, 2014 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:drink drivingJudge Paul KellyLetterkenny District CourtRodney Tighelast_img read more

first_imgA gala dinner marking the end of the Nicholl awards week in 2010. The late Gee Nicholl gives a speech at the 2001 event. (Images: Nicholl Fellowship in Screenwriting) MEDIA CONTACTS • Natalie Kojen  Publicist: Ampas RELATED ARTICLES • Made in 48 hours, Joburg style • African film is focus at Fespaco • Big grant for African filmmakers • SA filmmaker wins top enviro award • New Afrikaans film a hit Valencia TalaneThe Academy of Motion Picture Arts and Sciences (Ampas) in Hollywood will honour the latest recipients of the Nicholl Fellowship in Screenwriting at a gala dinner in Beverly Hills on Thursday 8 November.Among the five is South African filmmaker Sean Robert Daniels, from Pretoria in Gauteng. He wrote Killers, the story of a female contract killer whose dying mother asks her to come back to her hometown to end her life.As the story unfolds, it explores the relationship between the two women and the mother’s doctor.The 2012 edition of the competition had attracted over 7 000 entries from around the world, and since May the judges have been narrowing the entries down to the best five.“When I first discovered that I had been awarded the fellowship I felt stunned,” Roberts shared in an interview with Media Update in October. “It was a surreal experience.”For the past 26 years, Ampas – the body behind the Academy Awards, also known as the Oscars – has awarded these fellowships for the scripts that they consider most deserving.Exciting honourAn additional honour for Daniels is that he is the only non-American in the group, and the first South African to become a Nicholls fellow. The fellowships are each valued at US$35 000 (R301 969), with the money disbursed over the year of the fellowship, US$7 000 (R60 393) every quarter.To mark the beginning of their fellowship year, the group spends seven days in Los Angeles during the Nicholls awards week, where they are encouraged to network with industry experts during, and take part in, seminars. The week culminates in the awards dinner. Previous fellows also attend, along with the judging committee.The goal for the year ahead, according to the committee, is to have each of the fellows write a feature-length screenplay, the deadline of which is the end of the fellowship year.Finalists’ profiles are also distributed to producers, agents and executives in the field of talent development in LA to help encourage their entry into the world of film.Daniels studied film and television in Australia, completing an honours degree in screen arts. He currently lectures at the Open Window School of Visual Communication in Centurion, Pretoria. The school’s website recognises Daniels’s accomplishment as one of the notable achievements of 2012.Speaking about his excitement at the prospects of the year ahead, Daniels told Media Update that since the announcement of the winners, he had been approached by several producers from Hollywood. His students, he said, are the most excited, and he hoped that they can learn from his achievement that their own dreams of making films can happen.The competitionThe first Nicholls fellowship script to be made into a feature film, Closet Land, was written by Radha Bharadwaj, who had won a place in the programme in 1989, three years into its existence.Other notable scripts linked to the fellowship include Doug Atchison’s Akeelah and the Bee, a film that was released in 2000, starring Laurence Fishburne and Angela Basset. Atchison won a National Association for the Advancement of Coloured People Image Award for best screenplay.Transformers: Revenge of the Fallen, was co-written by 1996 fellow Ehren Kruger, who also wrote Arlington Road, The Ring and the forthcoming Transformers: Dark of the Moon.The screenplay for the Julia Roberts film Erin Brockovich, which was nominated in the 2000 Oscars, was written by a previous fellow, Susannah Grant.The fellowship was named – by his wife, actress and fellow writer Gee Nicholl – after producer and writer Don Nicholl, who died in 1980, five years before the programme was initiated.Having started as a competition only for aspiring writers in the US, it was broadened to accommodate writers from other countries whose scripts are written in English. One of the strict rules of the competition is that work translated from other languages does not qualify.last_img read more

first_imgLiverpool midfielder Fabinho: Alisson best goalkeeper in Englandby Freddie Taylor10 months agoSend to a friendShare the loveFabinho says Liverpool teammate Alisson is the Premier League’s best goalkeeper.The Brazilian’s gaffe allowed Jesse Lingard to equalise during Liverpool’s 3-1 victory over the Red Devils on Sunday.But Fabinho has stuck by his compatriot.”When we entered the locker room, we even talked, but I did not even focus on that,” he added. “[Alisson] came to comment, but I said “no, bro, let it go”.”These plays will always happen. And what are we going to talk about Alisson? He was very important in our qualification for the last 16 of the Champions League, days before.”Without a doubt, he is the best goalkeeper of the English League. There is a lot of confidence.” About the authorFreddie TaylorShare the loveHave your saylast_img read more

first_imgAbout the authorPaul VegasShare the loveHave your say Tottenham boss Pochettino: I know Beckham’s a fanby Paul Vegasa month agoSend to a friendShare the loveTottenham boss Mauricio Pochettino has revealed David Beckham is a fan of his team.Beckham told Pochettino he wished he was playing for Spurs after watching them demolish Crystal Palace 4-0. “I was talking with Beckham after the game and he said he wished he still played and that he played for Tottenham because this stadium is amazing,” said Pochettino in quotes reported by The Sun.”We haven’t played many games here and it’s important to make this our house.“With time we will be at home here and then it will become very difficult for opponents to win here.” last_img read more

first_imgWillian enjoying Chelsea veteran roleby Freddie Taylor25 days agoSend to a friendShare the loveChelsea winger Willian is enjoying his different role within the squad this season.The Brazilian is now one of the senior members of the team, given the youth injection from manager Frank Lampard this summer.And Willian is happy to pass on his knowledge to the youngsters. But he insists that he has a lot to offer on the pitch as well. More than anything, he is happy at the club.”I enjoy it a lot,” he said to the club’s website.”I enjoy myself, I enjoy it with my team-mates and I have pleasure to play with them and this is what I want – to have pleasure, play, enjoy myself on the pitch and get the results.” About the authorFreddie TaylorShare the loveHave your saylast_img read more